5-Bromo-2-fluoropyridine-3-carboxylic acid, 5-Bromo-3-carboxy-2-fluoropyridine
5-Bromo-2-fluoronicotinic acid
CAS: 29241-66-5
Molecular Formula: C6H3BrFNO2
5-Bromo-2-fluoropyridine-3-carboxylic acid, 5-Bromo-3-carboxy-2-fluoropyridine - Names and Identifiers
5-Bromo-2-fluoropyridine-3-carboxylic acid, 5-Bromo-3-carboxy-2-fluoropyridine - Physico-chemical Properties
| Molecular Formula | C6H3BrFNO2 |
| Molar Mass | 220 |
| Density | 1.903±0.06 g/cm3(Predicted) |
| Boling Point | 327.4±42.0 °C(Predicted) |
| Flash Point | 151.8°C |
| Vapor Presure | 8.22E-05mmHg at 25°C |
| pKa | 2.15±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.589 |
| MDL | MFCD06797939 |
5-Bromo-2-fluoropyridine-3-carboxylic acid, 5-Bromo-3-carboxy-2-fluoropyridine - Risk and Safety
| Hazard Class | IRRITANT |
5-Bromo-2-fluoropyridine-3-carboxylic acid, 5-Bromo-3-carboxy-2-fluoropyridine - Introduction
5-Bromo-2-fluoronicotinic acid, chemical formula C6H3BrFNO2, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless or yellow solid
-Melting point: 166-170 ° C
-Boiling point: 324.7 ° C
-Solubility: Soluble in water and some organic solvents
Use:
5-Bromo-2-fluoronicotinic acid has certain application value in organic synthesis, and is mainly used to prepare other compounds, such as drugs, pesticides, dyes, etc.
Method:
The preparation of 5-Bromo-2-fluoronicotinic acid is generally carried out by the following steps:
1. First, ethyl bromophenylacetate and hydrogen fluoride hydrofluoric acid solution are reacted to produce ethyl 2-fluoro-5-bromophenylacetate.
2. Then, ethyl 2-fluoro-5-bromophenyl acetate was hydrolyzed under the catalysis of cuprous iodide to obtain 5-Bromo-2-fluoronicotinic acid.
Safety Information:
The toxicity and danger of 5-Bromo-2-fluoronicotinic acid is not fully understood, so necessary safety precautions should be taken when using it in the laboratory. If wearing protective goggles, protective gloves and laboratory coats, ensure that the operating environment is well ventilated. Avoid inhalation, chewing or skin contact when handling the compound, and store it properly to prevent contamination by external substances. If ingested or exposed, seek medical help immediately.
Nature:
-Appearance: Colorless or yellow solid
-Melting point: 166-170 ° C
-Boiling point: 324.7 ° C
-Solubility: Soluble in water and some organic solvents
Use:
5-Bromo-2-fluoronicotinic acid has certain application value in organic synthesis, and is mainly used to prepare other compounds, such as drugs, pesticides, dyes, etc.
Method:
The preparation of 5-Bromo-2-fluoronicotinic acid is generally carried out by the following steps:
1. First, ethyl bromophenylacetate and hydrogen fluoride hydrofluoric acid solution are reacted to produce ethyl 2-fluoro-5-bromophenylacetate.
2. Then, ethyl 2-fluoro-5-bromophenyl acetate was hydrolyzed under the catalysis of cuprous iodide to obtain 5-Bromo-2-fluoronicotinic acid.
Safety Information:
The toxicity and danger of 5-Bromo-2-fluoronicotinic acid is not fully understood, so necessary safety precautions should be taken when using it in the laboratory. If wearing protective goggles, protective gloves and laboratory coats, ensure that the operating environment is well ventilated. Avoid inhalation, chewing or skin contact when handling the compound, and store it properly to prevent contamination by external substances. If ingested or exposed, seek medical help immediately.
Last Update：2024-04-09 21:01:54
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Product Name: 5-Bromo-2-Fluoronicotinic Acid Visit Supplier Webpage Request for quotation
CAS: 29241-66-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 29241-66-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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5-Bromo-2-fluoropyridine-3-carboxylic acid, 5-Bromo-3-carboxy-2-fluoropyridine
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